I-Anti- PIVKA -II Antibody, Igundane Monoclonal
Ulwazi oluvamile
Amaprotheni Abangelwa Ukungabi Nakho Kwe-Vitamin K noma I-Antagonist-II (PIVKA-II), eyaziwa nangokuthi i-Des-γ-carboxy-prothrombin (DCP), iwuhlobo olungavamile lwe-prothrombin.Ngokuvamile, izinsalela ze-prothrombin eziyi-10 ze-glutamic acid (Glu) kusizinda se-γ-carboxyglutamic acid (Gla) ezikhundleni 6, 7, 14, 16, 19, 20,25, 26, 29 kanye ne-32 zingu-γ-carboxylated ku-Glasi ngevithamini. -K encike ku-γ- glutamyl carboxylase esibindini bese ikhishelwa ku-plasma.Ezigulini ezine-hepatocellular carcinoma (HCC), i-γ-carboxylation ye-prothrombin ikhubazekile ukuze kwakhiwe i-PIVKA-II esikhundleni se-prothrombin.I-PIVKA-II ibhekwa njenge-biomarker esebenzayo eqondile ye-HCC.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 1E5 ~ 1D6 1E5 ~ 1E6 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa.Ukugcina isikhathi eside, sicela u-aliquot futhi ukugcine.Gwema imijikelezo yokuqanda nokuncibilika ephindaphindiwe. |
Ukuhlaziya Ukuqhathanisa
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-PIVKA-Ⅱ | AB0009-1 | 1F4 |
| AB0009-2 | 1E5 | |
| AB0009-3 | 1D6 | |
| AB0009-4 | 1E6 |
Qaphela: angenza amanani egcizelele ngokwesidingo sakho.
Izingcaphuno
1.Matsueda K , Yamamoto H , Yoshida Y , et al.I-Hepatoid carcinoma ye-pancreas ekhiqiza amaprotheni ebangelwa ukungabikho kwe-vitamin K noma i-antagonist II (PIVKA-II) ne-α-fetoprotein (AFP) [J].Ijenali ye-Gastroenterology, 2006, 41(10):1011-1019.
2.Viggiani, Valentina, Palombi,等.Iphrotheni elenziwa ukungabikho kwevithamini K noma umphikisi-II (PIVKA-II) akhule ngokukhethekile ezigulini zase-Italy ze-hepatocellular carcinoma.[J].I-Scandinavian Journal of Gastroenterology, 2016.
3.Simundic AM .Izincomo ezisebenzayo zokuhlaziywa kwezibalo kanye nokwethulwa kwedatha kujenali ye-Biochemia Medica[J].I-Biochemia Medica, 2012, 22(1).
4.Tartaglione S , Pecorella I , Zarrillo SR , et al.Amaprotheni Abangelwa I-Vitamin K Ukungabi Nakho II (PIVKA-II) njengento engaba khona ye-serological biomarker kumdlavuza we-pancreatic: ucwaningo lokuhlola[J].I-Biochemia Medica, 2019, 29(2).
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