I-Pharmacodynamics

I-Amoxicillin iyi-antibiotic ye-β-lactam enomphumela obanzi we-antibacterial.I-spectrum ye-antibacterial kanye nomsebenzi we-antibacterial ngokuyisisekelo kuyafana naleyo ye-ampicillin, futhi umsebenzi wokulwa namagciwane ngokumelene namagciwane amaningi we-Gram-positive ubuthakathaka kancane kunalowo we-penicillin.Inomthelela onamandla kumagciwane e-Gram-negative afana ne-Escherichia coli, i-Proteus, i-Salmonella, i-Haemophilus, i-Brucella ne-Pasteurella, kodwa la magciwane ajwayele ukumelana nemithi.Ayitholakali kalula ku-Pseudomonas aeruginosa.Ngenxa yokuthi ukumuncwa kwayo ezilwaneni ze-monogastric kungcono kune-ampicillin futhi ukugcwala kwayo egazini kuphakeme, kunomphumela ongcono wokwelapha ekuthelelekeni kwesistimu.Ilungele izifo zesistimu ezifana nesistimu yokuphefumula, uhlelo lomchamo, isikhumba kanye nezicubu ezithambile ezibangelwa amagciwane azwelayo.

I-Pharmacokinetics

I-Amoxicillin izinzile ku-asidi yesisu, futhi i-74% kuya ku-92% imuncwa ngemuva kokuphathwa ngomlomo ezilwaneni ezinegastric.Okuqukethwe kwepheshana lamathumbu kuthinta izinga lokumunca, kodwa hhayi izinga lokumunca, ngakho-ke kungenziwa ngokuphakelayo okuxubile.Ngemuva kokuthatha umthamo ofanayo ngomlomo, ukugcwala kwe-amoxicillin ku-serum yegazi kuphindwe izikhathi eziyi-1.5 kuye kwezi-3 kune-ampicillin.

(1) Ukuhlanganiswa kwalo mkhiqizo nama-aminoglycosides kungakhuphula ukugcwala kokugcina kubhaktheriya, okubonisa umphumela we-synergistic.(2) Ama-bacteriostatic asebenza ngokushesha njengama-macrolides, ama-tetracycline nama-amide alcohols aphazamisa umphumela wokubulala amagciwane walo mkhiqizo, futhi akufanele asetshenziswe ndawonye.

ama-antibiotics we-β-lactam.Ukwelashwa kwezifo ezithathelwanayo ze-amoxicillin-gram-positive kanye ne-gram-negative ezinkukhu.

Ngokusekelwe kulo mkhiqizo.Ukuphathwa ngomlomo: umthamo owodwa, nge-1kg isisindo somzimba, inkukhu 0.2-0.3g, kabili ngosuku, izinsuku ezingu-5;isiphuzo esixutshwe: nge-1L yamanzi, inkukhu 0.6g, izinsuku ezingu-3-5.

Inomphumela onamandla wokuphazamisa esitshalweni esivamile sepheshana lesisu.

(1) Akuvunyelwe ukubekela izinkukhu ngesikhathi sokubekela.

(2) Ukutheleleka kwebhaktheriya e-Gram-positive amelana ne-penicillin akufanele kusetshenziswe.

(3) Ukwabiwa kwamanje kanye nokusetshenziswa.

7 izinsuku izinkukhu.

shading, ukulondolozwa okuvaliwe