Ukukhuthaza iNkqubo yoPhuhliso lweziyobisi
Iinkcukacha zajikelele
ipotifoliyo ekumgangatho wokuqala kunye neyona ibalaseleyo yenzelwe ukujongana neemfuno zonyango ezingafezekiyo ngophuhliso lwe-mono kunye ne-bi-specific protein therapeutics, i-antibody conjugates yamachiza kunye ne-macrophage stimulating agents kwizigulane kwihlabathi jikelele.
Imbali
Ukufunyanwa kweteknoloji ye-monoclonal antibody (mAb) ngu-Kohler noMilstein ngo-1975 ibonelele ithuba lokudala izilwa-buhlungu njengeklasi yonyango (Kohler & Milstein, 1975).Izilwa-buhlungu ze-Monoclonal (mAbs) lelinye lawona maqonga asetyenziswa kakhulu amachiza kwizifo ezosulelayo okanye kunyango lomhlaza ngenxa yokuba ajolise ngokukhethekileyo kwiintsholongwane, iiseli ezosulelayo, iiseli ezinomhlaza, kunye neeseli zomzimba.Ngale ndlela, balamla ukupheliswa kweemolekyuli ezijoliswe kuzo kunye neeseli ezineziphumo ebezingalindelekanga ezimbalwa kunezinye iindlela zonyango.Ngokukodwa, i-mAbs yonyango lomhlaza inokubona iiproteni ezingaphezulu kweeseli kwiiseli ekujoliswe kuzo kwaye emva koko ibulale iiseli ekujoliswe kuzo ngeendlela ezininzi.
I-Humanization inciphisa kakhulu i-antibody's immunogenicity yonyango ebantwini, yenze ukuba ulawulo olungapheliyo lwenzeke.Inkqubela phambili enjalo kubuchwepheshe be-antibody ikhokelele kugqabhuko-dubulo kuphuhliso lwee-mabs zonyango kule minyaka ilishumi idlulileyo.Uluhlu lwezinto eziphuma kwi-antibody, ezibandakanya iiproteni ze-Fc-fusion, i-antibody-drug conjugates (ADCs), i-immunocytokines (i-antibody-cytokine fusions), kunye ne-antibody-enzyme fusions, nazo ziphuhlisiwe kwaye zenziwe urhwebo njengonyango olutsha.
Iziphumo zeziyobisi
Kwizigulane, amachiza amatsha ekujoliswe kuwo athetha imiphumo emibi embalwa, ukulaliswa kwezibhedlele ezimbalwa, ukuphucula umgangatho wobomi, ukunyuka kwemveliso, kwaye okubalulekileyo, ubomi obongezelelweyo.Kodwa uphuhliso lwamachiza yinkqubo ende nentsonkothileyo.
Isalathiso
U-Kohler G, uMilstein C. Iinkcubeko eziqhubekayo zeeseli ezidityanisiweyo ezikhupha i-antibody echazwe kwangaphambili.Indalo.1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Imarike yonyango lwe-monoclonal antibody.MAbs.2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Ipapashwe 2015 Jul 14. Ifumaneka apha https://pubmed.ncbi.nlm.nih.gov/26182432/.Ifikeleleke ngoJulayi 2020.
Reichert, JM, kunye noValge-Archer, VE (2007).Iindlela zophuhliso lonyango lomhlaza we-monoclonal antibody.Nat Rev Drug Discov 6, 349-356.
ULazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Ukwahluka kwe-antibody ye-Fc eyenziwe ngobunjineli enomsebenzi ophuculweyo wesiphumo.PNAS 103, 4005–4010.
Injineli yobuchwephesha ezinikeleyo ukukukhokela
Ngokweemfuno zakho zokwenyani, khetha eyona ndlela ifanelekileyo yoyilo kunye neenkqubo zokucwangcisa