Pharmacodynamics

I-Amoxicillin yi-β-lactam ye-antibiotic ene-antibacterial effect ebanzi.I-antibacterial spectrum kunye nomsebenzi we-antibacterial ngokusisiseko ziyafana nezo ze-ampicillin, kwaye umsebenzi we-antibacterial ngokuchasene neebhaktheriya ezininzi ze-Gram-positive buthathaka kancinci kunaleyo ye-penicillin.Inefuthe elinamandla kwiibhaktiriya ze-Gram-negative ezifana ne-Escherichia coli, i-Proteus, i-Salmonella, i-Haemophilus, i-Brucella kunye ne-Pasteurella, kodwa ezi bhaktiriya ziyakwazi ukumelana namachiza.Ayinabungozi kwiPseudomonas aeruginosa.Ngenxa yokuba ukufunxwa kwayo kwizilwanyana ze-monogastric kungcono kune-ampicillin kwaye ukuxinana kwayo kwegazi kuphezulu, kunesiphumo esingcono sonyango kusulelo lwenkqubo.Ilungele usulelo lwenkqubo olufana nenkqubo yokuphefumla, inkqubo yomchamo, ulusu kunye nezicubu ezithambileyo ezibangelwa ziibhaktheriya ezibuthathaka.

Pharmacokinetics

I-Amoxicillin izinzile kwi-asidi yesisu, kwaye i-74% ukuya kwi-92% ifunxa emva kokulawulwa komlomo kwizilwanyana ze-monogastric.Imixholo yendlela yesisu ichaphazela izinga lokufunxa, kodwa kungekhona iqondo lokufunxa, ngoko inokulawulwa ngokutya okuxutywe.Emva kokuthatha idosi efanayo ngomlomo, i-serum concentration ye-amoxicillin yi-1.5 ukuya kumaxesha ama-3 ngaphezulu kwe-ampicillin.

(1) Ukudibanisa le mveliso kunye ne-aminoglycosides kunokunyusa ukuxinwa kokugqibela kwiibhaktheriya, kubonisa umphumo we-synergistic.(2) Ii-bacteriostatic agents ezikhawulezayo ezifana ne-macrolides, i-tetracyclines kunye ne-amide alcohols ziphazamisa umphumo we-bactericidal wale mveliso, kwaye akufanele zisetyenziswe kunye.

β-lactam antibiotics.Kunyango lwe-amoxicillin-susceptible gram-positive kunye ne-gram-negative usulelo kwiinkukhu.

Ngokusekelwe kule mveliso.Ukulawulwa komlomo: idosi enye, nge-1kg ubunzima bomzimba, inkukhu 0.2-0.3g, kabini ngosuku, iintsuku ezi-5;isiselo esixutywe: nge-1L yamanzi, inkukhu 0.6g, iintsuku ezi-3-5.

Unempembelelo enamandla yokuphazamiseka kwi-flora eqhelekileyo yendlela yesisu.

(1) Akuvumelekanga ukuba iinkukhu ezizalela ngexesha lokubeka.

(2) Usulelo lwentsholongwane yegram-positive ekwaziyo ukumelana nepenicillin akufanele kusetyenziswe.

(3) Ulwabiwo lwangoku kunye nokusetyenziswa.

Iintsuku ezisi-7 zeenkukhu.

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