Ivermectin
Ivermectin
Ivermectin ke phofo e tšoeu ea kristale, ha e na monko.E qhibiliha ka bolokolohi ho methanol, ethanol, acetone, ethyl acetate, hoo e batlang e sa qhibilihe ka metsing, 'me e batla e le hygroscopic.Ivermectin ke semisynthetic macrolide multi-karolo lithibela-mafu, eo haholo-holo e na le ivermectin B1 (Bla + B1b) diteng tse seng ka tlase ho 95%, eo Bla diteng tse seng ka tlase ho 85%.
Molao-motheo oa Bongaka
Ivermectin na le khetha inhibitory e le hantle, ka tlama ho phahameng kamano e phahameng ea chloride dikanale le glutamate e le belofo ka lisele tsa methapo ea kutlo le lisele tse mesifa ea liphoofolo spinless, e isang ho inase ea permeability ea lera la sele ho chloride ions, e etsa hore hyperpolarization ea lisele tsa methapo ea kutlo. kapa lisele tsa mesifa, 'me li baka ho holofala kapa ho shoa ha likokoana-hloko.E boetse e sebelisana le likanale tsa chloride tsa li-valve tse ling tsa ligand, joalo ka neurotransmitter g-aminobutyric acid (GABA).Khetho ea sehlahisoa sena ke hobane liphoofolo tse ling tse anyesang ha li na likanale tsa glutamate-chloride ka har'a vivo, mme avermectin e na le kamano e tlase feela bakeng sa likanale tsa mammalian ligand-chloride.Sehlahisoa sena ha se khone ho kenella mokoallong oa mali-boko a motho.Onchocerciasis le strongyloidiasis le hookworm, ascaris, Trichuris trichiura, le mafu a Enterobius vermicularis.
Ho sebelisa
Ivermectin ke meriana e sebelisoang ho phekola mefuta e mengata ea likokoana-hloko.Ivermectin e sebelisoa ho phekola mafu a liphoofolo a bakoang ke liboko le li-ectoparasites.
Ivermectin e sebelisoa ka tloaelo ho laola liboko tsa parasitic ka har'a pampitšana ea gastrointestinal ea liphoofolo tse ruminant.Hangata likokoana-hloko tsena li kena phoofolong ha e fula, li feta mala, 'me li lula le ho hōla ka maleng, ka mor'a moo li hlahisa mahe a tlohang phoofolo ka mantle a eona 'me a ka hlasela makhulo a macha.Ivermectin e atleha ho bolaea tse ling, empa eseng kaofela, tsa likokoana-hloko tsena.Ka lintja hangata e sebelisoa e le prophylaxis khahlanong le heartworm.
Meriana ea bongaka ba liphoofolo, e sebelisoa ho thibela le ho phekola lefu la pelo le acariasis, har'a matšoao a mang.E ka nkoa ka molomo kapa ea sebelisoa letlalong bakeng sa tšoaetso ea ka ntle.Ivermectin ho pharaletseng sebelisoa bakeng sa nematodes gastrointestinal, lungworms, le parasitic arthropods ka likhomo, linku, lipere, le likolobe, nematodes mala a lintja, mites tsebe, Sarcoptes scabiei, filariae pelo, le microfilariae, le gastrointestinal nematodes ka popelong le ente.
Litokisetso
Ivermectin ente1% ,2% ,3.4%, 4%;
Ivermectin tharollo ea molomo 0,08%, 0,8%, 0,2%;
Ivermectin premix;
Ivermectin bolus;
Ivermectin tšela tharollo 0.5% ,1% ;
Ivermectin gel 0.4%
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