Anti-PIVKA-II Antibody, Mouse Monoclonal
Warbixin guud
Barootiinka uu keeno Faytamiin K Maqnaanshaha ama antagonist-II (PIVKA-II), oo sidoo kale loo yaqaan Des-γ-carboxy-prothrombin (DCP), waa nooc aan caadi ahayn oo prothrombin ah.Caadi ahaan, prothrombin's 10 glutamic acid hadhaaga (Glu) ee ku jira γ-carboxyglutamic acid (Gla) ee jagooyinka 6, 7, 14, 16, 19, 20,25, 26, 29 iyo 32 waa γ-carboxylated to vitamin Gla -K ku tiirsan γ- glutamyl karboksilase ee beerka ka dibna lagu qariyo balasmaha.Bukaanada qaba kansarka hepatocellular (HCC), γ-carboxylation ee prothrombin waa daciif si PIVKA-II loo sameeyo halkii prothrombin.PIVKA-II waxaa loo tixgaliyaa inuu yahay biomarker hufan oo u gaar ah HCC.
Guryaha
| Lammaanaha Talada | CLIA (La-qabsashada): 1E5 ~ 1D6 1E5 ~ 1E6 |
| daahirnimo | >95%, waxaa go'aamiyay SDS-PAGE |
| Habaynta kaydka | 20mM PB, 150mM NaCl, 0.1% Proclin 300, pH7.4 |
| Kaydinta | Ku kaydi xaaladaha nadiifka ah -20 ℃ ilaa -80 ℃ markaad hesho.Kaydinta muddada dheer, fadlan kala saar oo kaydi.Ka fogow qaboojinta soo noqnoqda iyo wareegyada dhalaalida. |
Falanqaynta Isbarbardhigga
Macluumaadka Dalabka
| Magaca Alaabta | BisadMaya | Aqoonsiga Clone |
| PIVKA-Ⅱ | AB0009-1 | 1F4 |
| AB0009-2 | 1E5 | |
| AB0009-3 | 1D6 | |
| AB0009-4 | 1E6 |
Fiiro gaar ah: tiro lagu habeyn karaa hadba baahidaada.
Xigasho
1.Matsueda K, Yamamoto H, Yoshida Y, iyo al.Kansarka cagaarshowga beeryarada ee soo saara borotiinka waxaa keenay fiitamiin K maqnaanshaha ama antagonist II (PIVKA-II) iyo α-fetoprotein (AFP) [J].Joornaalka Gastroenterology, 2006, 41 (10): 1011-1019.
2.Viggiani, Valentina, Palombi, 等.Barootiinka uu keeno fiitamiin K la'aanta ama antagonist-II (PIVKA-II) ayaa si gaar ah u kordhay bukaannada kansarka hepatocellular ee Talyaaniga.[J].Joornaalka Iskandaneefiyanka ee Gastroenterology, 2016.
3.Simundic AM .Talooyinka wax ku oolka ah ee falanqaynta tirakoobka iyo soo bandhigida xogta ee joornaalka Biochemia Medica[J].Biochemia Medica, 2012, 22(1).
4.Tartaglione S, Pecorella I, Zarrillo SR, iyo al.Protein uu keenay Faytamiin K Maqnaanshaha II (PIVKA-II) sida biomarker serological ee suurtogalka ah ee kansarka ganaca: daraasad tijaabo ah[J].Biochemi Medica, 2019, 29(2).
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