Fa'alauiloa le Fa'atupuina o Vailaau Fa'asaina
Fa'amatalaga Lautele
muamua-i-vasega ma sili-i-vasega faila ua mamanuina e faʻatautaia ai manaʻoga faʻafomaʻi taua e leʻi ausia e ala i le atinaʻeina o vailaʻau polotini faʻapitoa ma lua, faʻamaʻi vailaʻau faʻamaʻi faʻamaʻi ma macrophage stimulating agents mo tagata mamaʻi i le lalolagi atoa.
Talafaasolopito
O le su'eina o le eleele o le monoclonal antibody (mAb) tekinolosi e Kohler ma Milstein i le 1975 na maua ai le avanoa e fausia ai ni antibodies e avea o se vasega o togafitiga (Kohler & Milstein, 1975).Monoclonal antibodies (mAbs) o se tasi lea o fa'aoga vaila'au e sili ona fa'aogaina mo fa'ama'i fa'ama'i po'o togafitiga o le kanesa aua latou te filifilia fa'ama'i fa'ama'i, sela fa'ama'i, sela kanesa, e o'o lava i sela puipuia.I lenei auala, latou te faʻatalanoaina le faʻaumatiaina o mole mole ma sela e itiiti ifo aʻafiaga nai lo isi togafitiga faʻapitoa.Aemaise lava, e mafai e mAbs togafitiga o le kanesa ona iloa polotini i luga o sela i luga o sela taulaʻi ona faʻaumatia lea o sela faʻatatau i le tele o masini.
O le fa'atagata soifua e matua fa'aitiitia ai le immunogenicity ole antibody fa'afoma'i ile tagata, ma mafai ai ona fa'agasolo le fa'atonuga.O ia alualu i luma i tekinolosi antibody ua mafua ai le pa i le atinaʻeina o mAbs togafitiga i le sefulu tausaga talu ai.O se faasologa o mea e maua mai i le antibody, e aofia ai le Fc-fusion proteins, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), ma le antibody-enzyme fusions, o loʻo atiina ae ma faʻatauvaʻa o se togafitiga fou.
Aafiaga o fualaau faasaina
Mo tagata mama'i, o vaila'au fa'atatau fou o lona uiga e itiiti a'afiaga, fa'aitiitia falema'i, fa'aleleia le lelei o le olaga, fa'ateleina le gaosiga, ma le taua, ola fa'aumiumi.Ae o le atinaʻeina o vailaʻau o se faiga umi, faʻalavelave.
Fa'asinomaga
Kohler G, Milstein C. Fa'aauau aganu'u o sela fused fa'alilolilo antibody o fa'amanino fa'apitoa.natura.1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Le maketi monoclonal antibody togafitiga.MAbs.2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates o se tala fou e tetee atu i le kanesa chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Fa'asalalau 2015 Iulai 14. E maua ile https://pubmed.ncbi.nlm.nih.gov/26182432/.Avanoa ia Iulai 2020.
Reichert, JM, ma Valge-Archer, VE (2007).Atina'e aga'i mo monoclonal antibody togafitiga kanesa.Nat Rev Drug Discov 6, 349–356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Fa'ainisinia antibody Fc fa'atasi ma le fa'aleleia o galuega fa'atino.PNAS 103, 4005–4010.
Enisinia fa'apolofesa fa'apitoa fa'apitoa e ta'ita'ia oe
E tusa ai ma ou manaʻoga moni, filifili le ata sili ona talafeagai ma fuafuaga faʻatulagaina