Guteza imbere inzira yo guteza imbere ibiyobyabwenge
Amakuru rusange
icyiciro cya mbere-cy-icyiciro-cyiza-cy-icyiciro cyateguwe kugirango gikemure ibikenewe byubuvuzi bidakenewe hifashishijwe iterambere rya mono na bi-yihariye ivura poroteyine, imiti ya antibody hamwe na macrophage itera abarwayi ku isi yose.
Amateka
Ubuvumbuzi bwavumbuwe bwa tekinoroji ya monoclonal antibody (mAb) na Kohler na Milstein mu 1975 byatanze amahirwe yo gukora antibodi nk'icyiciro cyo kuvura (Kohler & Milstein, 1975).Antibodiyite za Monoclonal (mAbs) ni imwe mu miti ikoreshwa cyane mu ndwara zandura cyangwa kuvura kanseri kuko zihitamo kwibasira indwara ziterwa na virusi, selile zandura, selile kanseri, ndetse na selile selile.Muri ubu buryo, bahuza kurandura molekile hamwe ningirabuzimafatizo zifite ingaruka nke ugereranije nubundi buryo bwo kuvura.By'umwihariko, kanseri ivura mAbs irashobora kumenya poroteyine zo hejuru-selile kuri selile hanyuma ikica selile igenewe hakoreshejwe uburyo bwinshi.
Kuba umuntu bigabanya cyane ubudahangarwa bwa antibody yo kuvura abantu, bigatuma ubuyobozi budakira bushoboka.Iterambere nk'iryo mu buhanga bwa antibody ryatumye habaho guturika mugutezimbere imiti mAbs mu myaka icumi ishize.Urukurikirane rw'ibikomoka kuri antibody, birimo poroteyine za Fc-fusion, antibody-ibiyobyabwenge bya conjugate (ADCs), immunocytokine (antibody-cytokine fusions), hamwe na antibody-enzyme fusion, nabyo byatejwe imbere kandi bigacuruzwa nk'ubuvuzi bushya.
Ingaruka zibiyobyabwenge
Ku barwayi, imiti mishya igamije gusobanura ingaruka nkeya, ibitaro bike, kuzamura imibereho, kongera umusaruro, kandi cyane, ubuzima bwagutse.Ariko iterambere ryibiyobyabwenge ninzira ndende, igoye.
Reba
Kohler G, Milstein C. Imico ikomeza ya selile yahujwe isohora antibody yibintu byateganijwe mbere.Kamere.1975; 256: 495–497.doi: 10.1038 / 256495a0
Ecker DM, Jones SD, Levine HL.Isoko ryo kuvura antibody ya monoclonal.MAbs.2015; 7: 9–14.doi: 10.4161 / 19420862.2015.989042.
Peters C, Brown S. Antibody-ibiyobyabwenge bifata nkibintu bishya birwanya kanseri ya chimiotherapeutics.Biosci Rep. 2015; 35 (4): e00225.Yatangajwe 2015 Jul 14. Iraboneka kuri https://pubmed.ncbi.nlm.nih.gov/26182432/.Byemewe muri Nyakanga 2020.
Reichert, JM, na Valge-Archer, VE (2007).Iterambere ryiterambere rya monoclonal antibody kanseri ivura.Nat Rev Ibiyobyabwenge Discov 6, 349–356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, n'abandi.(2006).Antibody yakozwe na Fc ihindagurika hamwe nibikorwa byongerewe imbaraga.PNAS 103, 4005–4010.
Inzobere mu bya tekinike yabigize umwuga yitangiye kukuyobora
Ukurikije ibyo ukeneye mubyukuri, hitamo uburyo bushyize mu gaciro bwo gutegura no gutegura