Pramlintide Acetate CAS: 196078-30-5 Raw material supply
Product Description
Pramlintide (Symlin) is a relatively new injectable drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca )Pramlintide is sold as an acetate salt.
Pramlintide is an analogue of amylin ,a small peptide hormone that is released into the bloodstream by the β-cells of the pancreas along with insulin, after a meal.Like insulin, amylin is completely absent in individuals with Type I diabetes.
Reduction in glycated hemoglobin and weight loss have been shown in insulin-treated patients with type 2 diabetes taking pramlintide as an adjunctive therapy.
By augmenting endogenous amylin, pramlintide aids in the cellular absorption and regulation of blood glucose by slowing gastric emptying, promoting satiety via pothalamic receptors (different receptors than for GLP-1), and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin. Pramlintide also has effects in raising the acute first-phase insulin response threshold following a meal.
Company profile
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