o-Phthalaldehyde
Synonyms:Aldede, ortho-Phthalic;o Phthalaldede;o Phthaldialdede;o-Phthalaldede;o-Phthaldialdede;ortho Phthalaldede;ortho Phthalic Aldede;ortho-Phthalaldede;ortho-Phthalic Aldede;Orthophthaldialdede
Chemical Property of o-Phthalaldede
● Appearance/Colour:Light yellow powder
● Vapor Pressure:0.0088mmHg at 25°C
● Melting Point:55-58 °C(lit.)
● Refractive Index:1.622
● Boiling Point:266.1 °C at 760 mmHg
● Flash Point:98.5 °C
● PSA：34.14000
● Density:1.189 g/cm3
● LogP:1.31160
● Storage Temp.:2-8°C
● Sensitive.:Air Sensitive
● Solubility.:53g/l
● Water Solubility.:soluble
● XLogP3:1.2
● Hydrogen Bond Donor Count:0
● Hydrogen Bond Acceptor Count:2
● Rotatable Bond Count:2
● Exact Mass:134.036779430
● Heavy Atom Count:10
● Complexity:115
Safty Information
● Pictogram(s):T, Xi, N
● Hazard Codes:Xi,T,N,C
● Statements:36/37/38-43-34-25-50-52/53
● Safety Statements:26-28-36-45-36/37/39-61-37/39
Useful
Chemical Classes:Other Classes -> Benzaldedes
Canonical SMILES:C1=CC=C(C(=C1)C=O)C=O
Inhalation Risk:A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
Effects of Short Term Exposure:The substance is corrosive to the eyes and skin. The substance is irritating to the respiratory tract.
Effects of Long Term Exposure:Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Uses:o-Phthalaldede can be widely used for precolumn derivatization of amino acids in HPLC separation or Capillary electrophoresis. For flow cytometric measurements of protein thiol groups. o-Phthalaldede can be used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups. Precolumn derivatization reagent for primary amines and amino acids. The fluorescent derivative can be detected by reverse-phase HPLC. The reaction requires OPA, primary amine and a sulfdryl. In the presence of excess sulfdryl, amines can be quantitated. In the presence of excess amine, sulfdryls can be quantitated. Disinfectant. Reagent in fluorometric determination of primary amines and thiols.
Detailed Introduction
o-Phthalaldede, also known as 1,2-benzenedicarboxaldede or o-xylylene aldede, is an organic compound with the chemical formula C8H6O2. It is a colorless solid that is soluble in organic solvents such as alcohol and ether.
o-Phthalaldede is mainly known for its use as a disinfectant and sterilizing agent in medical and laboratory settings. It is commonly used for the disinfection of medical equipment, endoscopes, and dialysis machines. It has strong antimicrobial properties and is effective against a wide range of microorganisms including bacteria, viruses, and fungi.
The disinfectant properties of o-phthalaldede are attributed to its ability to inhibit the activity of enzymes required for the metabolism of microorganisms. It has a broad spectrum of activity and is particularly effective against mycobacteria, which are known to be difficult to eliminate with other disinfectants.
o-Phthalaldede is often used as an alternative to glutaraldede, another commonly used disinfectant. It has several advantages over glutaraldede, including faster disinfection times, improved stability, and less toxicity. It also has less odor and does not require the addition of an activator solution.
In addition to its disinfectant properties, o-phthalaldede is used in chemical synthesis and as a reagent in organic reactions. It can react with primary amines to form imine derivatives, which are versatile intermediates in organic chemistry. These imines can then be further modified to produce a wide range of products.
However, it is important to handle o-phthalaldede with caution as it can be toxic, irritating to the eyes, skin, and respiratory system. It should be used in well-ventilated areas, and appropriate personal protective equipment should be worn during handling. It is also important to follow recommended guidelines and regulations for its use as a disinfectant or in any other application.
Application
o-Phthalaldede has a variety of applications, primarily in the medical and laboratory fields. Here are some common uses of o-phthalaldede:
Disinfectant and sterilizing agent: o-Phthalaldede is widely used as a high-level disinfectant for medical equipment, including endoscopes, surgical instruments, and dialysis machines. It effectively kills a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
Surface disinfection: o-Phthalaldede is used for the disinfection of surfaces in healthcare facilities, laboratories, and cleanrooms. It can be applied to countertops, floors, and other hard surfaces to eliminate pathogens.
Water treatment: o-Phthalaldede can be applied in water treatment to control bacterial growth and ensure the safety of drinking water. It can effectively eliminate bacteria and other microorganisms commonly found in water sources.
Chemical synthesis: o-Phthalaldede is used as a reagent in organic synthesis, particularly in reactions involving primary amines. It can react with primary amines to form imines, which are important intermediates in the production of various organic compounds.
It is worth noting that o-phthalaldede is highly reactive and should be handled with care. Proper safety measures and guidelines should be followed when using o-phthalaldede in any application, and it is advisable to consult the manufacturer’s instructions and relevant regulatory agencies for specific guidance.
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