Kupezeka koyambilira kwaukadaulo wa monoclonal antibody (mAb) kopangidwa ndi Kohler ndi Milstein mu 1975 kunapereka mwayi wopanga ma antibodies ngati gulu lachipatala (Kohler & Milstein, 1975).Ma antibodies a Monoclonal (mAbs) ndi amodzi mwamapulatifomu omwe amagwiritsidwa ntchito kwambiri pamankhwala opatsirana kapena ochizira khansa chifukwa amasankha tizilombo toyambitsa matenda, ma cell opatsirana, maselo a khansa, komanso ma cell a chitetezo chamthupi.Mwanjira imeneyi, amayimira kuthetsa kwa mamolekyu ndi maselo omwe ali ndi zotsatira zochepa kusiyana ndi njira zina zochiritsira.Makamaka, mamAbs ochizira khansa amatha kuzindikira mapuloteni apakhungu pama cell omwe akuwatsata kenako ndikupha maselo omwe akuwunikiridwa ndi njira zingapo.
Kukhazikika kwaumunthu kumachepetsa kwambiri chitetezo chamthupi mwa anthu, kupangitsa kuti kuwongolera kosalekeza kutheke.Kupita patsogolo kotere mu matekinoloje a antibody kwadzetsa kuphulika kwa chitukuko cha ma mAbs ochizira m'zaka khumi zapitazi.Mitundu yambiri ya antibody fusions, yomwe imaphatikizapo mapuloteni a Fc-fusion, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), ndi ma fusions a antibody-enzyme, amapangidwanso ndikugulitsidwa ngati mankhwala atsopano.