Ivermectin
Ivermectin
Ivermectin ndi ufa woyera wa crystalline, wopanda fungo.Amasungunuka momasuka mu methanol, ethanol, acetone, ethyl acetate, pafupifupi osasungunuka m'madzi, komanso hygroscopic pang'ono.Ivermectin ndi semisynthetic macrolide Mipikisano gawo mankhwala, amene makamaka lili ivermectin B1 (Bla + B1b) zili osachepera 95%, amene Bla zili zosachepera 85%.
Mfundo ya Mankhwala
Ivermectin ali kusankha chopinga tingati, ndi kumanga kwa mkulu kuyanjana kwa kolorayidi ngalande ndi glutamate monga valavu mu mitsempha maselo ndi minofu maselo a spinless nyama, zomwe zimabweretsa inase wa permeability wa nembanemba selo kuti chloride ayoni, zimayambitsa hyperpolarization wa mitsempha maselo. kapena maselo a minofu, ndipo amachititsa ziwalo kapena kufa kwa tizilombo toyambitsa matenda.Imalumikizananso ndi njira za chloride za ma valve ena a ligand, monga neurotransmitter g-aminobutyric acid (GABA).Kusankhidwa kwa mankhwalawa ndi chifukwa chakuti zinyama zina zilibe njira za glutamate-chloride mu vivo, ndipo avermectin imakhala ndi chiyanjano chochepa cha mammalian ligand-chloride.Chida ichi sichingalowe mu chotchinga chamagazi chamunthu.Onchocerciasis ndi strongyloidiasis ndi nyongolotsi, ascaris, Trichuris trichiura, ndi matenda a Enterobius vermicularis.
Kugwiritsa
Ivermectin ndi mankhwala omwe amagwiritsidwa ntchito pochiza mitundu yambiri ya tizilombo toyambitsa matenda.Ivermectin imagwiritsidwa ntchito pochiza matenda a nyama omwe amayamba chifukwa cha mphutsi ndi ectoparasites.
Ivermectin nthawi zonse ntchito kulamulira parasitic nyongolotsi mu m`mimba thirakiti nyama ruminant.Tizilombo toyambitsa matenda timeneti timaloŵa m’chilombocho pamene ikudya msipu, timadutsa m’matumbo, n’kukhazikika ndi kukhwima m’matumbo, ndipo pambuyo pake timapanga mazira amene amachoka m’zitosi za nyamayo n’kugwera msipu watsopano.Ivermectin imathandiza kupha ena, koma osati onse, a tizilombo toyambitsa matenda.
Mu mankhwala Chowona Zanyama, amagwiritsidwa ntchito kupewa ndi kuchiza heartworm ndi acariasis, pakati pa zizindikiro zina.Itha kutengedwa pakamwa kapena kugwiritsidwa ntchito pakhungu chifukwa cha matenda akunja.Ivermectin chimagwiritsidwa ntchito m'mimba nematodes, mphutsi, ndi parasitic arthropods ng'ombe, nkhosa, akavalo, ndi nkhumba, nematodes m'mimba mu agalu, nthata khutu, Sarcoptes scabiei, mtima filariae, ndi microfilariae, ndi m'mimba nematodes ndi m'mimba nematodes.
Kukonzekera
Ivermectin jakisoni1%,2%,3.4%,4%;
Ivermectin m'kamwa njira 0,08%, 0,8%, 0,2%;
Ivermectin premix;
Ivermectin bolus;
Ivermectin kutsanulira-pa njira 0,5% ,1% ;
Ivermectin gel osakaniza 0.4%
Katswiri waukadaulo wodzipereka kukutsogolerani
Malingana ndi zosowa zanu zenizeni, sankhani ndondomeko yoyenera kwambiri yokonzekera ndikukonzekera