Product Informations

At present, there are many anti-tumor drugs, but no ideal anti-laryngocarcinoma drug with high efficiency and low toxicity has been found. Therefore, the study of high-efficiency, low-toxicity, and even natural anti-tumor drugs to enrich the prevention and treatment of laryngeal cancer has become the focus and focus of many experts and scholars. Indole-3-carbinol (indole-3-carbinol) is a tumor chemopreventive substance, which can be extracted from cruciferous vegetables (such as broccoli, radish and cauliflower, etc.). Indole-3-carbinol can inhibit the occurrence and development of various tumors.
1. Inhibitory effect of indole-3-carbinol on the proliferation of laryngeal carcinoma Hep-2 cells
Indole-3-carbinol can inhibit the proliferation of Hep-2 cells, and its induction of apoptosis may be related to the inhibition of Livin protein expression.
With the increase of indole-3-carbinol concentration, the expression of Livin gradually decreased, suggesting that the expression of Livin protein was negatively correlated with the apoptosis rate of human laryngeal carcinoma cell line Hep-2 after the action of indole-3-carbinol. It may play a certain role in the apoptosis of human laryngeal carcinoma cells induced by indole-3-carbinol. Indole-3-carbinol can only induce apoptosis of cancer cells, and is safe and non-cytotoxic to non-tumor cells. Because of its high-efficiency, non-toxic and natural anti-tumor properties, indole-3-carbinol can be one of the candidates for cancer prevention and treatment. The molecular mechanism of indole-3-carbinol inhibiting laryngeal cancer cells still needs further study in order to provide a theoretical basis for future clinical drug research.
2. Application areas
Health products and pharmaceutical intermediates.

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