Ivermectin
Ivermectin
Ivermectin bụ ọcha crystalline ntụ ntụ, enweghị isi.Ọ na-agbaze n'efu na methanol, ethanol, acetone, ethyl acetate, ọ fọrọ nke nta ka ọ ghara ịsacha ya na mmiri, yana ntakịrị hygroscopic.Ivermectin bụ ọgwụ nje nwere ọtụtụ akụkụ macrolide semisynthetic, nke kachasị nwere ivermectin B1 (Bla + B1b) nke na-erughị 95%, nke ọdịnaya Bla na-erughị 85%.
Ụkpụrụ Ọgwụ
Ivermectin nwere mmetụta inhibitory nhọrọ, site na ijikọ njikọ dị elu nke ọwa chloride na glutamate dị ka valvụ na mkpụrụ ndụ akwara na mkpụrụ ndụ anụ ahụ nke anụmanụ ndị na-enweghị spine, nke na-eduga n'inase nke permeability nke membranes cell na ion chloride, na-akpata hyperpolarization nke mkpụrụ ndụ akwara. ma ọ bụ mkpụrụ ndụ akwara, na-ebute mkpọnwụ ma ọ bụ ọnwụ nke nje.Ọ na-ejikọta ya na ọwa chloride nke valves ligand ndị ọzọ, dị ka neurotransmitter g-aminobutyric acid (GABA).Nhọrọ nke ngwaahịa a bụ n'ihi na ụfọdụ mammals enweghị ọwa glutamate-chloride na vivo, na avermectin nwere naanị obere mmekọrịta maka ọwa ligand-chloride mammalian.Ngwaahịa a enweghị ike ịbanye n'ihe mgbochi ụbụrụ-ọbara mmadụ.Onchocerciasis na strongyloidiasis na hookworm, ascaris, Trichuris trichiura, na Enterobius vermicularis ọrịa.
Iji
Ivermectin bụ ọgwụ eji agwọ ọtụtụ ụdị ọrịa nje.A na-eji Ivermectin agwọ ọrịa ụmụ anụmanụ nke roundworms na ectoparasites kpatara.
A na-ejikarị Ivermectin chịkwaa ikpuru na-egbu egbu n'ime eriri afọ nke anụmanụ ndị na-eri anụ.Ọrịa nje ndị a na-abanyekarị n'anụmanụ mgbe ọ na-ata nri, gafere afọ afọ, tinye ma tozuo n'ime eriri afọ, mgbe nke ahụ gasịrị, ha na-emepụta akwa na-esi n'anụmanụ pụọ n'anụmanụ ma nwee ike ịta ahịhịa ọhụrụ.Ivermectin dị irè n'igbu ụfọdụ, ma ọ bụghị ihe niile, n'ime nje ndị a. N'ime nkịta, a na-ejikarị ya eme ihe dị ka prophylaxis megide mgbu obi.
Na ọgwụgwọ ọrịa anụmanụ, a na-eji ya egbochi na ịgwọ ọrịa obi na acariasis, n'etiti ihe ngosi ndị ọzọ.Enwere ike were ya n'ọnụ ma ọ bụ tinye ya n'akpụkpọ ahụ maka ọrịa ndị dị n'èzí.A na-ejikarị Ivermectin eme ihe maka nematodes eriri afọ, lungworms, na parasitic arthropods na ehi, atụrụ, ịnyịnya, na ezì, nematodes intestinal na nkịta, ntị ntị, Sarcoptes scabiei, filariae obi, na microfilariae, na eriri afọ nematodes na ectoparasites na anụ ọkụkọ.
Nkwadebe
Ivermectin ịgba ogwu 1% ,2% ,3.4%, 4%;
Ihe ngwọta ọnụ nke Ivermectin 0.08%, 0.8%, 0.2%;
Ivermectin premix;
Ivermectin bolus;
Ivermectin wụsa-na ngwọta 0,5% ,1%;
Ivermectin gel 0.4%
Ọkachamara nka injinia raara onwe ya nye ka o duzie gị
Dabere na mkpa gị n'ezie, họrọ usoro nhazi na atụmatụ n'ozuzu kacha ezi uche dị na ya