Txhawb Txoj Kev Txhim Kho Tshuaj
Cov ntaub ntawv dav dav
thawj-hauv-chav kawm thiab cov ntaub ntawv zoo tshaj plaws hauv chav kawm yog tsim los daws cov kev xav tau kev kho mob tseem ceeb los ntawm kev txhim kho mono thiab bi-specific protein therapeutics, antibody tshuaj conjugates thiab macrophage stimulating agents rau cov neeg mob thoob ntiaj teb.
Keeb kwm
Kev tshawb pom hauv av ntawm monoclonal antibody (mAb) thev naus laus zis los ntawm Kohler thiab Milstein hauv xyoo 1975 tau muab qhov muaj peev xwm tsim cov tshuaj tiv thaiv kab mob raws li chav kho mob (Kohler & Milstein, 1975).Monoclonal antibodies (mAbs) yog ib qho ntawm cov tshuaj siv ntau tshaj plaws rau cov kab mob sib kis los yog kev kho mob qog noj ntshav vim lawv xaiv cov kab mob, cov kab mob sib kis, cov kab mob qog noj ntshav, thiab txawm tias lub cev tiv thaiv kab mob.Nyob rau hauv txoj kev no, lawv kho qhov kev tshem tawm ntawm lub hom phiaj molecules thiab cov hlwb uas muaj kev phiv tsawg dua li lwm cov kev kho mob.Tshwj xeeb, kev kho mob qog noj ntshav mAbs tuaj yeem paub cov cell-nto proteins ntawm lub hom phiaj hlwb thiab tom qab ntawd tua cov phiaj hlwb los ntawm ntau lub tswv yim.
Humanization zoo heev txo cov tshuaj tiv thaiv kab mob tiv thaiv kab mob hauv tib neeg, ua rau kev tswj hwm ntev.Xws li kev nce qib hauv cov thev naus laus zis tshuaj tiv thaiv tau ua rau muaj kev tawg hauv kev txhim kho ntawm kev kho mAbs nyob rau xyoo kaum xyoo dhau los.Ib cov tshuaj tiv thaiv kab mob, uas suav nrog Fc-fusion proteins, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), thiab antibody-enzyme fusions, kuj tau tsim thiab ua lag luam raws li kev kho tshiab.
Tshuaj cuam tshuam
Rau cov neeg mob, cov tshuaj siv tshuaj tshiab txhais tau tias muaj kev phiv tsawg dua, kev pw hauv tsev kho mob tsawg dua, txhim kho lub neej zoo, nce kev tsim khoom, thiab qhov tseem ceeb, kev ua neej ntev.Tab sis kev txhim kho tshuaj yog qhov ntev, txheej txheem nyuaj.
Kev siv
Kohler G, Milstein C. Nruam kab lis kev cai ntawm fused hlwb secreting antibody ntawm predefined tshwj xeeb.Xwm.1975; 256: 495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Therapeutic monoclonal antibody kev lag luam.MAB.2015; 7:9–14.doi: 10.4161/19420862.2015.989042 ib.
Peters C, Brown S. Antibody-drug conjugates li tshiab anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Luam tawm 2015 Lub Xya Hli 14. Muaj nyob ntawm https://pubmed.ncbi.nlm.nih.gov/26182432/.Nkag mus rau Lub Xya Hli 2020.
Reichert, JM, thiab Valge-Archer, VE (2007).Kev txhim kho tiam sis rau kev kho mob qog noj ntshav monoclonal antibody.Nat Rev Drug Discov 6, 349–356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Engineered antibody Fc variants nrog kev ua haujlwm zoo dua qub.NPAS 103, 4005–4010.
Cov kws tshaj lij technical engineer mob siab rau coj koj
Raws li koj qhov kev xav tau tiag tiag, xaiv qhov tsim nyog tshaj plaws thiab cov txheej txheem kev npaj