Ivermectin
Ivermectin
Ivermectin yog dawb crystalline hmoov, tsw tsw.Nws yog dawb do soluble hauv methanol, ethanol, acetone, ethyl acetate, xyaum insoluble hauv dej, thiab me ntsis hygroscopic.Ivermectin yog ib qho tshuaj tua kab mob semisynthetic macrolide ntau yam, uas feem ntau muaj ivermectin B1 (Bla + B1b) cov ntsiab lus tsis tsawg dua 95%, ntawm cov ntsiab lus Bla tsis tsawg dua 85%.
Txoj Cai ntawm Tshuaj
Ivermectin muaj cov nyhuv inhibitory, los ntawm kev khi rau siab affinity ntawm chloride raws nrog glutamate li lub valve hauv paj hlwb thiab cov leeg hlwb ntawm spinless tsiaj, uas ua rau inase ntawm permeability ntawm cell membranes rau chloride ions, ua rau hyperpolarization ntawm paj hlwb. los yog cov leeg nqaij, thiab ua rau tuag tes tuag taw lossis tuag ntawm cov cab.Nws kuj cuam tshuam nrog cov tshuaj chloride ntawm lwm cov ligand li qub, xws li cov neurotransmitter g-aminobutyric acid (GABA).Qhov kev xaiv ntawm cov khoom no yog vim qee cov tsiaj txhu tsis muaj glutamate-chloride raws hauv vivo, thiab avermectin tsuas muaj kev sib raug zoo rau cov tsiaj txhu ligand-chloride raws.Cov khoom no tsis tuaj yeem nkag mus rau tib neeg cov ntshav-hlwb barrier.Onchocerciasis thiab strongyloidiasis thiab hookworm, ascaris, Trichuris trichiura, thiab Enterobius vermicularis kab mob.
Siv
Ivermectin yog cov tshuaj siv los kho ntau hom kab mob cab.Ivermectin yog siv los kho tsiaj cov kab mob tshwm sim los ntawm roundworms thiab ectoparasites.
Ivermectin yog ib txwm siv los tswj cov kab mob cab hauv plab hnyuv ntawm cov tsiaj ruminant.Cov kab mob no feem ntau nkag mus rau tus tsiaj thaum nws yog grazing, dhau lub plab zom mov, thiab teeb tsa thiab loj hlob hauv cov hnyuv, tom qab ntawd lawv tsim cov qe uas tawm hauv tus tsiaj los ntawm nws cov xau thiab tuaj yeem kis tau cov pastures tshiab.Ivermectin muaj txiaj ntsig zoo hauv kev tua qee tus, tab sis tsis yog txhua tus, ntawm cov kab mob no.Nyob rau hauv dev nws yog ib txwm siv los tiv thaiv kab mob plawv.
Hauv cov kws kho tsiaj, nws yog siv los tiv thaiv thiab kho mob plawv thiab acariasis, nrog rau lwm cov kev qhia.Nws tuaj yeem raug coj los ntawm qhov ncauj lossis siv rau ntawm daim tawv nqaij rau cov kab mob sab nraud.Ivermectin yog dav siv rau plab hnyuv nematodes, lungworms, thiab parasitic arthropods nyob rau hauv nyuj, yaj, nees, thiab npua, plab hnyuv nematodes nyob rau hauv dev, pob ntseg mites, Sarcoptes scabiei, plawv filariae, thiab microfilariae, thiab gastrointestinal nematodes.
Kev npaj
Ivermectin txhaj 1%, 2%, 3.4%, 4%;
Ivermectin qhov ncauj daws 0.08%, 0.8%, 0.2%;
Ivermectin premix;
Ivermectin bolus;
Ivermectin ncuav 0.5%, 1%;
Ivermectin gel yog 0.4%
Cov kws tshaj lij technical engineer mob siab rau coj koj
Raws li koj qhov kev xav tau tiag tiag, xaiv qhov tsim nyog tshaj plaws thiab cov txheej txheem kev npaj