Pharmacodynamics

Amoxicillin yog ib qho tshuaj tua kab mob β-lactam nrog dav-spectrum antibacterial nyhuv.Cov tshuaj tua kab mob thiab cov kab mob tua kab mob yog qhov zoo ib yam li cov tshuaj ampicillin, thiab cov tshuaj tua kab mob tiv thaiv kab mob Gram-positive feem ntau yog me ntsis qis dua li ntawm penicillin.Nws muaj cov txiaj ntsig zoo ntawm cov kab mob Gram-tsis zoo xws li Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella thiab Pasteurella, tab sis cov kab mob no nquag ua rau cov tshuaj tiv thaiv.Tsis raug rau Pseudomonas aeruginosa.Vim tias nws qhov nqus tau zoo hauv cov tsiaj txhu monogastric zoo dua li ntawm ampicillin thiab nws cov ntshav concentration siab dua, nws muaj txiaj ntsig zoo rau cov kab mob hauv lub cev.Nws yog qhov tsim nyog rau cov kab mob hauv lub cev xws li ua pa, ua pa, tso zis, tawv nqaij thiab cov nqaij mos uas tshwm sim los ntawm cov kab mob rhiab heev.

Pharmacokinetics

Amoxicillin yog qhov ruaj khov rau cov kua qaub hauv plab, thiab 74% mus rau 92% yog nqus tau tom qab kev tswj hwm qhov ncauj hauv cov tsiaj txhu.Cov ntsiab lus ntawm lub plab zom mov cuam tshuam rau tus nqi ntawm kev nqus, tab sis tsis yog qhov nqus ntawm qhov nqus, yog li nws tuaj yeem siv rau hauv kev pub mis sib xyaw.Tom qab noj tib koob tshuaj ntawm qhov ncauj, cov ntshav ntawm amoxicillin yog 1.5 mus rau 3 npaug siab dua li ntawm ampicillin.

(1) Kev sib xyaw ua ke ntawm cov khoom no nrog aminoglycosides tuaj yeem ua kom cov concentration ntawm cov kab mob tom kawg, uas qhia txog kev sib koom ua ke.(2) Cov kab mob bacteriostatic sai sai xws li macrolides, tetracyclines thiab amide alcohols cuam tshuam cov kab mob bactericidal ntawm cov khoom no, thiab yuav tsum tsis txhob siv ua ke.

β-lactam tshuaj tua kab mob.Rau kev kho mob ntawm amoxicillin-susceptible gram-positive thiab gram-negative kab mob hauv qaib.

Raws li cov khoom no.Kev tswj qhov ncauj: ib koob, ib 1kg lub cev hnyav, nqaij qaib 0.2-0.3g, ob zaug ib hnub, rau 5 hnub;sib tov dej: ib 1L dej, nqaij qaib 0.6g, rau 3-5 hnub.

Nws muaj zog cuam tshuam rau lub cev muaj zog ntawm lub plab zom mov.

(1) Nws yog txwv tsis pub tso hens thaum lub sij hawm tso.

(2) Gram-positive kab mob resistant rau penicillin yuav tsum tsis txhob siv.

(3) Kev faib thiab siv tam sim no.

7 hnub rau qaib.

shading, kaw ruaj khov