Pharmacodynamics

ʻO Amoxicillin kahi antibiotic β-lactam me ka hopena antibacterial ākea ākea.Ua like ka hana antibacterial spectrum a me ka hana antibacterial me ka ampicillin, a ʻo ka hana antibacterial e kūʻē i ka hapa nui o nā maʻi bacteria Gram-positive ʻoi aku ka nāwaliwali ma mua o ka penicillin.He hopena koʻikoʻi ia i ka maʻi bacteria Gram-negative e like me Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella a me Pasteurella, akā hiki i kēia mau bacteria ke kū'ē i ka lāʻau.ʻAʻole maʻalahi i ka Pseudomonas aeruginosa.No ka mea, ʻoi aku ka maikaʻi o ka lawe ʻana i loko o nā holoholona monogastric ma mua o ka ampicillin a ʻoi aku ka kiʻekiʻe o ke koko, ʻoi aku ka maikaʻi o ka hoʻōla ʻana i ka maʻi ʻōnaehana.He kūpono ia no nā maʻi ʻōnaehana e like me ka ʻōnaehana hanu, ka ʻōnaehana urinary, ka ʻili a me nā ʻiʻo palupalu i hoʻokumu ʻia e ka maʻi bacteria.

Pharmacokinetics

Paʻa loa ʻo Amoxicillin i ka waikawa gastric, a ʻo 74% a 92% ka mea i hoʻopaʻa ʻia ma hope o ka lawelawe waha i nā holoholona monogastric.ʻO nā mea i loko o ka'ōpū o ka'ōpū e pili i ka helu o ka absorption, akā,ʻaʻole i ke kiʻekiʻe o ka absorption, no laila hiki ke lawelaweʻia i ka hānaiʻana.Ma hope o ka lawe waha like ʻana, ʻo ka nui o ka serum o ka amoxicillin he 1.5 a 3 mau manawa kiʻekiʻe ma mua o ka ampicillin.

(1) Hiki i ka hui pū ʻana o kēia huahana me nā aminoglycosides ke hoʻonui i ka neʻe ʻana o ka hopena i loko o ka bacteria, e hōʻike ana i kahi hopena synergistic.(2) ʻO nā mea hana bacteriostatic wikiwiki e like me macrolides, tetracyclines a me ka amide alcohols e hoʻopilikia i ka hopena bactericidal o kēia huahana, a ʻaʻole pono e hoʻohana pū ʻia.

nā lāʻau lapaʻau β-lactam.No ka mālama ʻana i ka amoxicillin-susceptible gram-positive a me ka gram-negative maʻi i nā moa.

Ma muli o kēia huahana.ʻO ka hoʻoponopono waha: hoʻokahi dosis, no ka 1kg kaumaha o ke kino, moa 0.2-0.3g, ʻelua i ka lā, no 5 mau lā;inu hui: no 1L o ka wai, moa 0.6g, no 3-5 lā.

Loaʻa iā ia kahi hopena interference ikaika i ka flora maʻamau o ka gastrointestinal tract.

(1) Ua pāpā ʻia ka hoʻomoe ʻana i nā moa i ka wā hoʻomoe.

(2) ʻAʻole pono e hoʻohana ʻia ka maʻi bacteria Gram-positive kūʻē i ka penicillin.

(3) Hoʻokaʻawale a hoʻohana i kēia manawa.

7 lā no nā moa.

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