Introduction

Human Enterovirus 71 IgG ELISA Kit is an enzyme-linked immunosorbent assay for the qualitative detection of IgG-class antibodies to Enterovirus 71 in human serum or plasma. It is intended to be used in clinical laboratories for diagnosis and management of patients related to infection with Enterovirus 71.

The main clinical manifestation of EV71 infection is hand, foot and mouth disease. Some children with EV71 infection present with herpetic pharyngitis, and in severe cases, viral encephalitis, viral encephalomyelitis, pulmonary oedema and pulmonary haemorrhage.

The specific diagnosis of EV71 infection relies on the detection of EV71-RNA, EV71-IgM and EV71-IgG antibodies in serum, or EV71-RNA in swab specimens.

EV71-IgM is an important indicator of primary or recent infection and facilitates early detection and treatment of EV71 infection. EV71-IgG is an important indicator for differential diagnosis of infection and can be used for epidemiological investigation and evaluation of vaccination. It can be used for epidemiological investigation and evaluation of the effect of vaccination. The change of antibody titers in both recovered and acute blood can also determine the EV71 infection, and if the titer of serum antibody increases geometrically by 4 in the recovered period compared with the acute period, then it can be judged as EV71 presenting infection.