N-formyl derivative 4 was obtained by reflux of 2 in formic acid for 5 hours at a high yield. Acetic acid N’-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]-hydrazide (5) was obtained by reflux acetylation of 2 in acetic acid at a good yield. Compound 6 is also obtained by refluxing 2 with 3-(2-bromoacetyl) -4-hydroxy-2 H-chromen-2-one in ethanol. Compound 2 reacts with phenyl isothiocyanate in ethanol at room temperature to obtain 4-phenyl-1-(7-hydroxy-2-oxo-2 H-chromen-4-acetyl -)-thiosemicarbazide (7).
3-{2-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]hydrazono}butanoate (8) ethyl ester (8), 3-{2-[2-(7-hydroxy-2-oxo-2 H-Chromen-4-yl)-acetyl] Hydrazono} Butanoate (8), The yield was 48% (Option 2). The structure of compounds 4-8 was determined by their analytical data and their IR and 1 H-NMR spectra. The infrared absorption due to NH, OH and C=O functions appears at 3450-3000 and 1728-1610cm-1, respectively. Absorption bands associated with the presence of other functional groups are present in the expected region. The 1 H-NMR spectrum of the compound shows a single peak in the 8.03-10.58ppm region corresponding to NH and OH protons. Compound 4-8