Pharmacodynamics

Amoxicillin is a β-lactam antibiotic with broad-spectrum antibacterial effect. The antibacterial spectrum and antibacterial activity are basically the same as those of ampicillin, and the antibacterial activity against most Gram-positive bacteria is slightly weaker than that of penicillin. It has a strong effect on Gram-negative bacteria such as Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella and Pasteurella, but these bacteria are prone to drug resistance. Not susceptible to Pseudomonas aeruginosa. Because its absorption in monogastric animals is better than that of ampicillin and its blood concentration is higher, it has better curative effect on systemic infection. It is suitable for systemic infections such as respiratory system, urinary system, skin and soft tissue caused by sensitive bacteria.

Pharmacokinetics

Amoxicillin is quite stable to gastric acid, and 74% to 92% is absorbed after oral administration in monogastric animals. The contents of the gastrointestinal tract affect the rate of absorption, but not the degree of absorption, so it can be administered in mixed feeding. After taking the same dose orally, the serum concentration of amoxicillin is 1.5 to 3 times higher than that of ampicillin.

(1) Combination of this product with aminoglycosides can increase the concentration of the latter in bacteria, showing a synergistic effect. (2) Fast-acting bacteriostatic agents such as macrolides, tetracyclines and amide alcohols interfere with the bactericidal effect of this product, and should not be used together.

β-lactam antibiotics. For the treatment of amoxicillin-susceptible gram-positive and gram-negative infections in chickens.

Based on this product. Oral administration: one dose, per 1kg body weight, chicken 0.2-0.3g, twice a day, for 5 days; mixed drink: per 1L of water, chicken 0.6g, for 3-5 days.

It has a strong interference effect on the normal flora of the gastrointestinal tract.

(1) It is forbidden for laying hens during the laying period.

(2) Gram-positive bacterial infection resistant to penicillin should not be used.

(3) Current allocation and use.

7 days for chickens.

 shading, sealed preservation