Poly amino acids (polypeptide) materials have excellent biocompatibility, biological activity and degradability. They have been widely used in  drugs and gene delivery, tissue engineering, polypeptides, and antibacterial areas. In the past centuries, scholars in many international polymer areas have been explored and optimized NCA aggregation; amidamine has caused NCA aggregation to be the most widely used way to this day. However, this NCA aggregation method is slow (usually it takes 2-3 days to complete), and it is difficult to prepare a large molecular measurement polypeptide; at the same time, due to the poor stability of the NCA monomer, long-term reactions may lead to side reactions. produce. The more prominent disadvantage is that the NCA aggregation is highly sensitive to water. The aggregation reaction is generally performed under the protection of inert gas in the glove box, which limits the application of parallel polypeptide molecular libraries and large -scale synthesis. The core problems and challenges that these NCA aggregates have not been solved have hindered the further development of this field and the application of polypeptides in many fields.