White crystalline powder; Insoluble in water and petroleum ether, soluble in etl acetate and methanol; mp is 115-116℃; Specific rotation [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
Used for polypeptide synthesis, as an amino acid protection monomer.
O-benzyl-l-threonine was suspended in dioxane solution and acylated with tert-butylcarbonyl azide to obtain a crude product, which was extracted by etl acetate at pH of 9-10 and then recrystallized.
An active part of tmic oietin Ⅱ of tmus secretions. Tmoietin II is a single polypeptide compound isolated from tmus hormone. It is composed of 49 amino acids, and the peptide chain fragment composed of 5 amino acids has all the same psiological functions as tmoietin II. Therefore, this pentapeptide fragment is called tmus pentapeptide. White freeze-dried loose mass or powder.
One of the roles of tmus pentapeptide is to induce T cell differentiation. It can selectively induce the transformation of T-1- prothorax cells into T-1+ T cells. T cell differentiation is mediated by increased intracellular cAMP levels. Another basic function of tmus pentapeptides is to bind to specific receptors of mature peripheral blood T cells, increase intracellular cAMP level, and thus induce a series of intracellular reactions, which is also the basis of its immunomodulatory function. In normal body condition, tmus pentapeptide showed immune stimulating effect, which could significantly increase the E rosette formation rate and conversion rate of splenic lymphocytes, enhance the different stages of the primary or secondary immune response, and increase the number of IgM type and IgG or IgA type antibody forming cells. Tmus pentapeptide can also enhance the phagocytosis function of macrophages, increase the enzyme and phagocytosis function of polymorphonuclear neutrophils, increase the circulating antibody content, and enhance the immune function of red blood cells. Tmus pentapeptide can activate CD4 and CD8 positive cells, so that specific Tc cells can maintain longer life, but also can activate Th cells and induce the function of Ts cells. The antiinfectious and therapeutic effects of tmus pentapeptide are related to its enhancement of TC cell activity. An appropriate amount of tmus pentapeptide can significantly increase the production of interferon in anti-infection immunity. Inducing and promoting T cell differentiation and maturation; CD4/CD8 tended to be normal by regulating the proportion of T lymphocyte subsets; Enhance the phagocytosis function of macrophages; Enhance red blood cell immune function; Increase the activity of natural killer cells; Increase the level of interleukin-2 production and receptor expression; Enhance the production of γ interferon in peripheral blood mononuclear cells; Enhance SOD activity in serum.
It can be used in malignant tumor patients with immune function impairment after radiotherapy and chemotherapy. Treatment of hepatitis B; Major surgical operations and severe infections; Autoimmune diseases such as rheumatoid arthritis, lupus erythematosus; Type II diabetes mellitus, menopause syndrome; A person with weakened immune function.